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Throughout the implementation of the Montreal Protocol, developing countries have demonstrated that, with the right kind of assistance, they are willing, ready and able to be full partners in global efforts to protect the environment. In fact, many developing countries have exceeded the reduction targets for phasing out ODS, with the support of the Multilateral Fund.
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Another group of substances, hydrofluorocarbons (HFCs), were introduced as non-ozone depleting alternatives to support the timely phase-out of CFCs and HCFCs. HFCs are now widespread in air conditioners, refrigerators, aerosols, foams and other products. While these chemicals do not deplete the stratospheric ozone layer, some of them have high GWPs ranging from 12 to 14,000. Overall HFC emissions are growing at a rate of 8% per year and annual emissions are projected to rise to 7-19% of global CO2 emissions by 2050. Uncontrolled growth in HFC emissions, therefore, challenges efforts to keep global temperature rise at or below 2C this century. Urgent action on HFCs is needed to protect the climate system.
The issue has been under negotiation by the Parties since 2009 and the successful agreement on the Kigali Amendment (Decision XXVIII/1 and accompanying Decision XXVIII/2) continues the historic legacy of the Montreal Protocol. The Kigali Amendment will enter into force on 1 January 2019 for those countries that have ratified the amendment.
With the full and sustained implementation of the Montreal Protocol, the ozone layer is projected to recover by the middle of this century. Without this treaty, ozone depletion would have increased tenfold by 2050 compared to current levels, and resulted in millions of additional cases of melanoma, other cancers and eye cataracts. It has been estimated, for example, that the Montreal Protocol is saving an estimated two million people each year by 2030 from skin cancer.
Given all of these factors and more, the Montreal Protocol is considered to be one of the most successful environmental agreements of all time. What the parties to the Protocol have managed to accomplish since 1987 is unprecedented, and it continues to provide an inspiring example of what international cooperation at its best can achieve.
Animal models of fusariosis have been developed to study the pathogenicity of Fusarium species. Immunocompetent and neutropenic mice were challenged with F. solani conidia. Mortality correlated with inoculum size. In nonneutropenic mice the infection was characterized by necrotizing abscesses with hyphae, hemorrhage, and neutrophil and macrophage infiltration. By contrast, neutropenic mice did not exhibit an inflammatory cellular reaction and had a significantly higher fungal burden (57).
Among immunocompetent hosts, lesions are usually localized (13 of 14 patients) and occur after skin breakdown (trauma or preexisting onychomycosis). Three patients presented with ulcerated lesions resembling chromoblastomycosis. The single case of disseminated metastatic skin lesion occurred in a child with no apparent underlying disease who developed fever, pulmonary infiltrates, multiple erythematous papules and nodules, and several blood cultures yielding Fusarium sp. Two cases of mycetoma caused by Fusarium spp. have been recently reported (107, 113).
Coffee may affect how cancer develops, ranging from the initiation of a cancer cell to its death. For example, coffee may stimulate the production of bile acids and speed digestion through the colon, which can lower the amount of carcinogens to which colon tissue is exposed. Various polyphenols in coffee have been shown to prevent cancer cell growth in animal studies. Coffee has also been associated with decreased estrogen levels, a hormone linked to several types of cancer.  Caffeine itself may interfere with the growth and spread of cancer cells.  Coffee also appears to lower inflammation, a risk factor for many cancers.
Although ingestion of caffeine can increase blood sugar in the short-term, long-term studies have shown that habitual coffee drinkers have a lower risk of developing type 2 diabetes compared with non-drinkers. The polyphenols and minerals such as magnesium in coffee may improve the effectiveness of insulin and glucose metabolism in the body.
Naturally occurring polyphenols in both caffeinated and decaffeinated coffee can act as antioxidants to reduce damaging oxidative stress and inflammation of cells. It may have neurological benefits in some people and act as an antidepressant.  Caffeine may affect mental states such as increasing alertness and attention, reducing anxiety, and improving mood.  A moderate caffeine intake of less than 6 cups of coffee per day has been associated with a lower risk of depression and suicide. However in a few cases of sensitive individuals, higher amounts of caffeine may increase anxiety, restlessness, and insomnia. Suddenly stopping caffeine intake can cause headache, fatigue, anxiety, and low mood for a few days and may persist for up to a week. 
Honduras was home to several important Mesoamerican cultures, most notably the Maya, before the Spanish colonization in the sixteenth century. The Spanish introduced Catholicism and the now predominant Spanish language, along with numerous customs that have blended with the indigenous culture. Honduras became independent in 1821 and has since been a republic, although it has consistently endured much social strife and political instability, and remains one of the poorest countries in the Western Hemisphere. In 1960, the northern part of what was the Mosquito Coast was transferred from Nicaragua to Honduras by the International Court of Justice.
The literal meaning of the term "Honduras" is "depths" in Spanish. The name could either refer to the bay of Trujillo as an anchorage, fondura in the Leonese dialect of Spain, or to Columbus's alleged quote that "Gracias a Dios que hemos salido de esas honduras" ("Thank God we have departed from those depths").
However, Copán represents only a fraction of Honduran pre-Columbian history. Remnants of other civilizations are found throughout the country. Archaeologists have studied sites such as Naco [es] and La Sierra in the Naco Valley, Los Naranjos on Lake Yojoa, Yarumela in the Comayagua Valley, La Ceiba and Salitron Viejo (both now under the Cajón Dam reservoir), Selin Farm and Cuyamel in the Aguan valley, Cerro Palenque, Travesia, Curruste, Ticamaya, Despoloncal, and Playa de los Muertos in the lower Ulúa River valley, and many others.
This interest in regional agreements may have increased the alarm of establishment politicians. When Zelaya began calling for a "fourth ballot box" to determine whether Hondurans wished to convoke a special constitutional congress, this sounded a lot to some like the constitutional amendments that had extended the terms of both Hugo Chávez and Evo Morales. "Chávez has served as a role model for like-minded leaders intent on cementing their power. These presidents are barely in office when they typically convene a constitutional convention to guarantee their reelection," said a 2009 Spiegel International analysis, which noted that one reason to join ALBA was discounted Venezuelan oil. In addition to Chávez and Morales, Carlos Menem of Argentina, Fernando Henrique Cardoso of Brazil and Columbian President Álvaro Uribe had all taken this step, and Washington and the EU were both accusing the Sandinista National Liberation Front government in Nicaragua of tampering with election results. Politicians of all stripes expressed opposition to Zelaya's referendum proposal, and the Attorney-General accused him of violating the constitution. The Honduran Supreme Court agreed, saying that the constitution had put the Supreme Electoral Tribunal in charge of elections and referenda, not the National Statistics Institute, which Zelaya had proposed to have run the count. Whether or not Zelaya's removal from power had constitutional elements, the Honduran constitution explicitly protects all Hondurans from forced expulsion from Honduras.
A new administrative division called ZEDE (Zonas de empleo y desarrollo económico) was created in 2013. ZEDEs have a high level of autonomy with their own political system at a judicial, economic and administrative level, and are based on free market capitalism.
Land appears to be plentiful and readily exploitable, but the presence of apparently extensive land is misleading because the nation's rugged, mountainous terrain restricts large-scale agricultural production to narrow strips on the coasts and to a few fertile valleys. Honduras's manufacturing sector has not yet developed beyond simple textile and agricultural processing industries and assembly operations. The small domestic market and competition from more industrially advanced countries in the region have inhibited more complex industrialization.
Economic growth in the last few years has averaged 7% a year, one of the highest rates in Latin America (2010). Despite this, Honduras has seen the least development amongst all Central American countries. Honduras is ranked 130 of 188 countries with a Human Development Index of .625 that classifies the nation as having medium development (2015). The three factors that go into Honduras's HDI (an extended and healthy life, accessibility of knowledge and standard of living) have all improved since 1990 but still remain relatively low with life expectancy at birth being 73.3, expected years of schooling being 11.2 (mean of 6.2 years) and GNI per capita being $4,466 (2015). The HDI for Latin America and the Caribbean overall is 0.751 with life expectancy at birth being 68.6, expected years of schooling being 11.5 (mean of 6.6) and GNI per capita being $6,281 (2015).
Because much of the Honduran economy is based on small scale agriculture of only a few exports, natural disasters have a particularly devastating impact. Natural disasters, such as 1998 Hurricane Mitch, have contributed to this inequality as they particularly affect poor rural areas. Additionally, they are a large contributor to food insecurity in the country as farmers are left unable to provide for their families. A study done by Honduras NGO, World Neighbors, determined the terms "increased workload, decreased basic grains, expensive food, and fear" were most associated with Hurricane Mitch. 041b061a72